Synapt g2si high definition mass spectrometry by waters corporation. Hi colleagues, we realy do want some feedback from users of synapt g2 hdms system. Waters introduced the synapt g2 system at the 57th american society for mass spectrometry asms conference on mass spectrometry and allied topics in philadelphia, pa. Through highefficiency twave ion mobility user can get superior separation, enhance the peak capacity. With the synapt g2 high definition ms system from waters, youll explore a dimension of data that was previously unavailable. Synapt g2 ms with quantof technology and high definition. Waters the waters synapt g2 hdms is a refurbished 2010 high resolution exact mass msms platform that provides a new dimension of performance to drive scientific discovery. Features quantitative quadrupole timeofflight mass spectrometer quantoftm high resolution exact msms travelling wave ion mobility separation twavetm video overview of the twavetm technology. Synapt g2 and g1 both have similar instrument schematic except few differences in the ims cell. The synapt hdms system is a flexible research platform providing. Waters synapt hdms system enables the analysis of samples differentiated by size and shape, as well as mass, to deliver increased specificity and sample definition beyond that achievable by conventional mass spectrometers. I am trying to analyze small molecule data collected using waters synapt g2.
With unique flexibility through an extensive range of analytical capabilities, synapt combines highefficiency twave ion mobility measurements and separations with highperformance ms, enabling the differentiation of samples by size, shape and charge, as well as mass. Synapt provides the most complete characterization of complex mixtures and molecules with unique levels of ms performance, industry leading informatics and unparalleled platform versatility. The second generation synapt tm g2 platform from waters corporation provides a new dimension of performance to drive your scientific discovery like never before. The hdms upgrade will enable you to differentiate samples based on size, shape, and charge, as well as mass.
Through highefficiency twave ion mobility user can get superior separation, enhance the peak capacity, specificity and sensitivity of the analysis and. Synapt is the ultimate research discovery platform providing unsurpassed qualitative and quantitative performance. The collision cross section of a molecule is an important distinguishing feature that is directly related to its chemical structure and threedimensional conformation in the. See inside the synapt g2 mass spectrometer from waters corp. Synapt g2si hdms 2011 waters corporation 4 waters hdx workflow. Maldi synapt g2si hdms combines twave ims and quantof technology within a streamlined imaging workflow to deliver unparalleled selectivity, clarity and confidence. Synapt high definition mass spectrometry is the combination of highefficiency ion mobility measurements and separations with highperformance tandem ms, enabling the differentiation. The synapt g2 system is capable of outstanding qualitative and quantitative performance for both ms and the elevated data acquisition rates of synapt g2 hdms analysis. We know the theoretical aspects and specifications of the system.
In the example shown in the attached ppt file, there are three major peaks for oleic acid mz 281. Waters maldi synapt g2 hdms the maldi synapt g2 hdms system is a hybrid, quadrupole, ion mobility, orthogonal acceleration, timeofflight oatof mass spectrometer controlled by masslynx software. Maldi synapt g2si high definition mass spectrometry. Waters synapt g2 hdms shared instrumentation network. Synapt g2si hdms redefining resolution resolution in 3 dimensions. Waters synapt g2si quadrupoleion mobilitytof hybrid instrument serves a broad range of applications by providing the most extensive range of targeted data acquisition.
By upgrading your synapt tm ms series instrument to full hdms tm capability you can take advantage of high efficiency ion mobility separations ims to extend your research to a new dimension. What is the latest version of masslynx software for the. Combine stepwave and uplc separations with quantof, for the highest peak capacity and data quality. Synapt provides the most complete characterization of complex mixtures and molecules with unique levels of ms performance, industry leading in. Features quantitative quadrupole timeofflight mass spectrometer quantoftm high resolution exact msms travelling wave ion mobility separation triwavetm cell, incl. Synapt g2s i is the only way to combine three dimensions of resolution, to access unique levels of separation, selectivity, sensitivity and structural insight. Minneapolis, june 10, 20 prnewswire via comtex waters corporation wat, 3. The synapt hdms system combines highefficiency ion mobility separations ims and tandem mass spectrometry to provide increased specificity and sample defintion. Weve combined quantof tm breakthrough quantitative tof technology and enhanced high definition ms tm techn ologies to provide you with. What is the latest version of masslynx software for the synapt g2s.
Synapt g2 hdms waters the mclean group laboratory for. The waters synapt g2 hdms is a refurbished 2010 high resolution exact mass msms platform that provides a new dimension of performance to drive scientific discovery. The waters synapt g2s high definition mass spectrometry provides complete characterization of complex mixtures and molecules with unique levels of ms performance, industry leading informatics and unparalleled platform versatility. Stepwave is the most sensitive and robust ion source available through its unique ability to actively select ions and passively reject neutral contaminants. It has an electrospray ionization esi interface, meaning that analytes need to be dissolved in mixture of aqueousorganic solution e. In comparison with synapt g2si hdms, the ims cell is. Through highefficiency twave ion mobility you can get superior separation, enhance the peak capacity, specificity and sensitivity of your analysis and.
A uniquely powerful and versatile platform for imaging, life science research and chemical material. If you are familiar with them and able to visit our facility you. When you want to reach beyond the boundaries of conventional mass spectrometry, synapt g2 high definition mass spectrometry hdms provides a new dimension to your discovery. Groundbreaking, high efficiency ion mobility separations combined with high resolution ms allow you to look beyond intense peaks and see new components at lower levels. However, the chromatograms shown by skyline look quite different from the ones by masslynx. Synapt g2 high definition mass spectrometer duke gcb. Waters introduces new synapt g2 with greater power.
It is fitted with a dualorthogonal api source lockspray esiapci. Sometimes chromatography and mass resolution are not enough. Synapt g2 is a qtof hybrid instrument, mainly used for small molecule mass analysis and hydrogendeuterium exchangemass spectrometry hdxms. Trap twave, ims twave, transfer twave stepwavetm ion optics video overview of the stepwavetm technology. Designed for leading researchers working at the limits of conventional mass spectrometery capabilities who need to further characterize and define their samples, waters synapt tm hdms tm system offers unique, enabling functionality waters synapt hdms tm system enables analysis of samples differentiated by size and shape and mass, to deliver. What is the latest version of masslynx software for the synapt g2.
The waters synapt g2si high definition mass spectrometry provides complete characterization of complex mixtures and molecules with unique levels of ms performance, industry leading informatics and unparalleled platform versatility. The synapt g2s system provides a unique platform to further your discovery efforts by expanding on the capabilities of conventional ms instrumentation. Waters introduces xevo g2xs qtof and xevo tqs micro mass. Ccs, from the new waters synapt g2si hdms mass spectrometer. Customer service customer experience point of sale lead management event management survey. However the unifi software is quite tricky to operate initially. With highefficiency twave ion mobility, you can use an additional dimension of separation, based on molecular size and shape. The instrument incorporates the newest technologies in the area of ion optics and ion mobility separation, with interchangeable universal ion source architecture, allowing. High efficiency ion mobility separations combined with high resolution ms allow you to look beyond intense peaks and see new components at lower levels. Synapt g1 high definition mass spectrometer duke gcb. Maldi synapt g2si high definition mass spectrometry the only way to access multiple dimensions of resolution for the highest levels of separation, specificity and confidence in analysis. Waters synapt g2si hdms the synapt g2si high definition mass spectrometer from waters is a hybrid quadrupole, ion mobility, orthogonal acceleration timeofflight oatof mass spectrometer that combines high resolution mass spectrometry with high efficiency ion mobilitybased measurements and separation ims.
Synapt g2 hdms is a high resolution exact mass msms platform designed to get you to the right result, faster no matter how challenging your application is. The hdi maldi solution provides a unique range of powerful multiplex targeted imsmsms and untargeted imsms e workflows from imagecentric method setup to data processing and image generation. Lcmaldi specific proteins from within complex mixtures that are only ionized by maldi, can also be accommodated by first carrying out liquid chromatography separations followed by ms analyses. System overview this chapter describes the instrument, including its controls, sources, and intellistart fluidics system contents topic page waters synapt g2 ms synapt g2 ms uplcmsms systems software instrument sources intellistart fluidics system ion optics 112 analyzers 1 mass spectrometer configuration. These are the primary instruments we use for our research purpose. The system combines exactmass, high resolution mass. Why we need such feedback is that we are currently considering to buy a qtof system and we will place a tender open competition to provide the best system from waters, agilent, bruker, sciex, and leco. For other instruments, see what is the latest version of masslynx that supports my instrument. Accounting billing and invoicing budgeting payment processing. Synapt g2s hdms waters the mclean group laboratory. The maldi synapt g2 hdms series instruments with their additional ion mobility separation capability also offers the possibility of ground breaking experimentation in new areas of research. By bringing together waters unique ion mobilityhigh resolution mass spectrometry platform with petroorg petroleomics software, analytical chemists can easily. The synapt g2si system exemplifies waters continuing commitment to innovation in mass spectrometry and collaborating with researchers on their journey of exploration.
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